Fork-First FertilityReferences
Hundreds of peer-reviewed studies show that what you eat directly impacts fertility outcomes. Here's the research that supports a Fork-First approach.
353 studies
"In this large-scale cross-sectional study, multiple logistic regression analysis showed that the intake of vitamins A, B1, B2, B6, C and folate was negatively associated with the occurrence of endometriosis."
The association between vitamin intake and endometriosis.
Reproductive health
Xu T, Zhuang Y, Cao H.
"Couples with male and female partners who consumed eight or more seafood servings per cycle had 47% and 60% greater fecundity (shorter TTP) than couples with male and female partners who consumed one or fewer seafood servings per cycle."
Seafood Intake, Sexual Activity, and Time to Pregnancy.
The Journal of clinical endocrinology and metabolism
Gaskins AJ, Sundaram R, Buck Louis GM et al.
"We discovered that factors such as smoking per day, smoking initiation, body mass index, basal metabolic rate, waist-to-hip ratio, whole body fat mass, trunk fat mass, overall health rating ... showed a significant effect on heightening genetic susceptibility of PCOS."
Causal relationships between modifiable risk factors and polycystic ovary syndrome.
Frontiers in endocrinology
Zhao Y, Pang J, Fang X et al.
"The possible relationship between the quality and quantity of micronutrients and macronutrients and PCOS as well as the necessity to manage PCOS as a complex condition highlights the importance of diet-related interventions."
An overview on effects of micronutrients and macronutrients interventions in management of polycystic ovary syndrome.
Clinical nutrition ESPEN
Saei Ghare Naz M, Jahanfar S, Ramezani Tehrani F.
"There was suggestive evidence of favorable associations between Mediterranean diet adherence with fertility and gestational weight management."
Mediterranean diet and female reproductive health over lifespan.
American journal of obstetrics and gynecology
Yang J, Song Y, Gaskins AJ et al.
"This exploratory study suggests that higher intakes of specific fatty acids are related to some PCOS phenotypes although no association was found for PCOS on a global basis."
Fat intake pattern in women with polycystic ovary syndrome.
Reproductive biomedicine online
Navarro-Lafuente F, Arense-Gonzalo JJ, Sánchez-Ferrer ML et al.
"Our study demonstrates that increased LE8 scores are associated with reduced infertility risk, providing an effective strategy for female infertility prevention."
Association between Life's Essential 8 and women infertility from the National Health and Nutrition Examination Survey 2013-2018.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Xu X, Liu R.
"Reducing or eliminating gluten, reducing or eliminating dairy, and the low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet were the most commonly reported dietary strategies utilized."
Dietary Practices of Women with Endometriosis.
Journal of alternative and complementary medicine (New York, N.Y.)
Armour M, Middleton A, Lim S et al.
"In addition to weight-loss, reducing dietary AGEs intake resulted in significantly greater improvements in metabolic and hormonal profiles among phenotype-A PCOS patients."
Comparison of Metabolic and Hormonal Profiles between Low-Advanced Glycation End Products (AGEs) and Standard AGEs-Containing Weight-Loss Diets in Overweight Phenotype-A PCOS Patients.
Reproductive sciences (Thousand Oaks, Calif.)
Ozdemir M, Mumusoglu S, Bilgic P.
"Our data suggest that high dietary inflammatory index (score) was associated with an increased odds of PCOS diagnosis."
The dietary inflammatory index is directly associated with polycystic ovary syndrome.
Clinical endocrinology
Zirak Sharkesh E, Keshavarz SA, Nazari L et al.
"Time-restricted feeding (TRF) may also improve hyperandrogenism, menstrual irregularities, and IR."
The Efficacy of Various Weight Loss Strategies in Alleviating Polycystic Ovary Syndrome.
Current obesity reports
Yang S, Pan X, Yang R et al.
"Vitamin B12 deficiency is rampant among reproductive age women (and) gets exacerbated by PCOS or vegetarian diet."
Impact of Prevalent Dietary Pattern on Serum Vitamin B12 Status and Its Association With Inflammation Among Reproductive Age Women.
Molecular nutrition & food research
Ganie MA, Bashir R, Sehar T et al.
"Alternative diets, such as the Mediterranean, anti-inflammatory, vegetarian, low-nickel and low-FODMAP diets, have also been presented in the context of their potential beneficial effects on the course of endometriosis."
I Am the 1 in 10-What Should I Eat? A Research Review of Nutrition in Endometriosis.
Nutrients
Piecuch M, Garbicz J, Waliczek M et al.
"the results suggest that the VLCKD is an optimal choice for entry into IVF, especially in terms of the time range in which these results are achieved."
The Impact of Nutritional Therapy in the Management of Overweight/Obese PCOS Patient Candidates for IVF.
Nutrients
Meneghini C, Bianco C, Galanti F et al.
"High uric acid levels are associated with metabolic disorders and an increased risk of anovulation."
Association of uric acid and fructose levels in polycystic ovary syndrome.
Human reproduction (Oxford, England)
Feng D, Wang X, Song J et al.
Changes in Hormonal Profile and Body Mass Index in Women with Polycystic Ovary Syndrome After Probiotic Intake.
Nutrients
Szydłowska I, Nawrocka-Rutkowska J, Gorzko A et al.
"PCOS women differ significantly from weight matched controls in the timings of their breakfast and lunch intake rather than the total caloric intake and macronutrient distribution."
PCOS patients differ in meal timings rather than total caloric or macronutrient intake in comparison to weight matched controls.
European journal of obstetrics, gynecology, and reproductive biology
Kulshreshtha B, Sharma N, Pant S et al.
"Reproduction ability requires a certain amount of body fat that is necessary for ovulation, menstruation and pregnancy."
The association between leptin, adiponectin levels and the ovarian reserve in women of reproductive age.
Frontiers in endocrinology
Nikolettos K, Vlahos N, Pagonopoulou O et al.
"Omega-3 fatty acids promote indirect benefits in the treating of women with PCOS."
Omega-3 supplementation in the treatment of polycystic ovary syndrome (PCOS) - a review of clinical trials and cohort.
Endocrine regulations
Melo V, Silva T, Silva T et al.
"There was a significant positive association between Body Roundness Index (BRI) and infertility."
Higher body roundness index (BRI) increases infertility among U.S. women aged 18-45 years.
BMC endocrine disorders
Gong H, Duan S, Choi S et al.
"The LGI-diet group had 85.4% more oocytes retrieved than did the control group in the IVF cycle."
Short-term effects of a hypocaloric diet with low glycemic index and low glycemic load on body adiposity, metabolic variables, ghrelin, leptin, and pregnancy rate in overweight and obese infertile women.
The American journal of clinical nutrition
Becker GF, Passos EP, Moulin CC.
"Therefore, we recommend this intervention to women with PCOS and excess weight, provided that a clinically relevant weight loss is being pursued."
Metabolic health during a randomized controlled lifestyle intervention in women with PCOS.
European journal of endocrinology
Dietz de Loos A, Jiskoot G, Beerthuizen A et al.
The effects of nutrients on symptoms in women with endometriosis.
Reproductive biomedicine online
Huijs E, Nap A.
Obesity and polycystic ovary syndrome influence on intestinal permeability at fasting, and modify the effect of diverse macronutrients on the gut barrier.
Food research international (Ottawa, Ont.)
Martínez-García MÁ, Quintero-Tobar A, de Lope Quiñones S et al.
"Our results showed that infertile women with PCOS and obesity and non-PCOS obese controls responded largely similarly to our lifestyle intervention and achieved the same level of improvement in markers of cardiometabolic health."
Effectiveness of a 6-Month Lifestyle Intervention on Diet, Physical Activity, Quality of Life, and Markers of Cardiometabolic Health in Women with PCOS and Obesity and Non-PCOS Obese Controls.
Nutrients
Wang Z, Groen H, Cantineau AEP et al.
"A one-year weight reduction program does not affect circulating AMH levels despite significant weight loss neither in women with PCOS, nor without PCOS and severe obesity."
Circulating Anti-Müllerian hormone in a cohort-study of women with severe obesity with and without polycystic ovary syndrome and the effect of a one-year weight loss intervention.
Reproductive biology and endocrinology : RB&E
Kataoka J, Larsson I, Lindgren E et al.
"The results of this systematic review indicate that EPA is suggested to have anti-inflammatory properties and may serve as a potential marker for illness severity."
The effect of two anti-inflammatory dietary components, omega-3 and resveratrol, on endometriosis.
Ginekologia polska
Sienko A, Cichosz A, Urban A et al.
"In conclusion, these findings suggest that 8 weeks of probiotic supplementation may alleviate oxidative stress, modulate certain hormonal factors, and reduce inflammation in women with PCOS."
Effects of supplementation with two probiotic strains (Lactobacillus helveticus and Bifidobacterium longum) on hormonal status, oxidative stress, and clinical symptoms in women with polycystic ovary syndrome.
Nutrition journal
Shirani M, Bagherniya M, Sadeghi O et al.
"While women with PCOS are more prone to weight gain, lifestyle factors have a more profound impact on weight gain in women with PCOS than without PCOS."
Weight gain and lifestyle factors in women with and without polycystic ovary syndrome.
Human reproduction (Oxford, England)
Awoke MA, Earnest A, Joham AE et al.
"A significant decrease in endometriosis-related pain was found in three out of five studies on vitamins, four out of six studies on fatty acids, one study on probiotics, two studies on medicinal plants, and five out of six studies on bioactive compounds."
The effects of oral nutritional supplements on endometriosis-related pain.
Journal of gynecology obstetrics and human reproduction
Julio T, Fenerich BA, Halpern G et al.